Plasma fibroblast therapy is an aesthetic procedure offered as an alternative to laser, injections, or surgical therapies to tighten and improve the appearance of skin. Plasma fibroblast therapy targets fibroblasts. These are collagen– and protein-producing cells in the dermis, the layer of skin just below your outermost skin layer.
Fibroblasts play an important role in helping skin wounds heal as well as maintaining skin firmness and tightness. Plasma fibroblast therapy uses a pen-like device that discharges a high-frequency electric current to small areas of the skin. The plasma tip doesn’t directly touch the skin, but instead releases a targeted current just above the skin. The hot current creates small holes, or micro-injuries, in the skin’s layer. According to an 2019 article published in the PMFA journal, the thermal disruption, or heat damage, from plasma fibroblast therapy:
- breaks down proteins in the skin
- encourages tissue regeneration
- stimulates fibroblast activity
- causes tissue contraction (tightening)
What are the benefits of plasma fibroblast therapy?
Plasma fibroblast therapy is a nonsurgical treatment that may be used to treat the following conditions:
- acne scars
- photo aging, including age spots
- seborrheic keratosis
- wrinkled skin, including the eyelids, neck, jawline, and above the lips
What’s the procedure like?
While the procedure may vary slightly based on where you’re having the treatment, the basic steps typically include:
- Cleansing the skin and applying a topical anesthetic (numbing) cream. You may need to wait about 30 minutes for the numbing cream to take effect.
- Treating the designated skin area with the plasma pen. The pen will create small arcs of microcurrents that make small scab-like dots on the skin.
- A professional will remove the numbing cream and apply a cooling gel to minimize the tingling and burning sensation whenever possible.
The procedure usually takes about 30 to 60 minutes to perform.
Once the procedure is completed, you can expect the small dots to scab over and fall off after about 1 week. Over the next couple of weeks, as your skin heals, it should appear tighter and firmer.
Some people may see benefits from one treatment, while others may require three treatments before they see results.
Who’s a good candidate for this procedure?
The best candidates for this procedure are people with mild-to-moderate skin wrinkling concerns.
You shouldn’t receive plasma fibroblast therapy if you:
- are breastfeeding
- are pregnant
- have an allergy to topical anesthetic preparations
- have an infection at the treatment site
- are using isotretinoin for wrinkles or acne
In addition, if you have a history of keloids or hypertrophic scarring, it’s recommended that you approach plasma fibroblast therapy with caution.
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- Bogle MA, et al. (2007). Evaluation of plasma skin regeneration technology in low-energy full-facial rejuvenation. DOI:
- Chuang J, et al. (2016). Overview of facial plastic surgery and current developments. DOI:
- Crofford R. (2019). A review of plasma medicine.
- Kamakura T, et al. (2015). Platelet-rich plasma with basic fibroblast growth factor for treatment of wrinkles and depressed areas of the skin. DOI:
- Loesch MM, et al. (2014). Skin resurfacing procedures: New and emerging options. DOI:
- What is Plasma Fibroblast Therapy? Written by Rachel Nall, MSN, CRNAon January 17, 2020 , https://www.healthline.com/health/plasma-fibroblast